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Recently，Beijing Key Laboratory of Veterinary Medicine (Traditional Chinese Medicine), Beijing Agricultural College"Research on the Antibacterial Mechanism of Traditional Chinese MedicineTeam”respectivelyFront Cell Infect MicrobiolandFront Cell Dev BiolTwo consecutive articles titled were published in a series of magazines“Comparison of the gut microbiota between Pulsatilla Decoction and levofloxacin hydrochloride therapy on Escherichia coli infection”and“Endothelial-derived interleukin-1α activates innate immunity by promoting the bactericidal activity of transendothelial neutrophils”.

To clarify Chinese medicineCompoundAntibacterial action mechanism, theTeam over the yearsAdhering to traditional Chinese medicine compound antibacterial multi-targets、Multi-utility research plan，Dedicated to researchAntibacterial medicine compound and its active ingredientsMechanism。Combined with TCM syndrome differentiation theory，Emphasis on the relationship between the antibacterial effect of traditional Chinese medicine and the host’s natural immunity and microenvironment，Established a variety of microvesselsEndothelial cells and neutrophils antibacterial interaction platform,Study on the antibacterial regulation of microvascular endothelial cells on innate immunity，bet365 online casinoSo that the platform can better serve the screening of antibacterial Chinese medicine prescriptions and their active ingredients。

To study the action targets of traditional Chinese medicine compounds，The team selected classic formula that has the functions of clearing away heat and detoxifying、The Chinese herbal compound Pulsatilla Decoction, which has the effect of cooling blood and stopping dysentery, treats diarrhea induced by Escherichia coli。This prescription is compared with the antibiotic levofloxacin in the treatment of diarrhea caused by E. coli infection，And detect the changes in the composition of intestinal flora after treatment (Figure1）。Both drugs can effectively treat diarrhea caused by pathogenic bacterial infection，But the results showed that Pulsatilla decoction caused less inflammatory response。After treatment with Pulsatilla Decoction，The composition of intestinal microorganisms has not changed much，Levofloxacin destroys the composition of intestinal microorganisms (Figure2). Among them, the main ingredient is Pulsatilla SoupBy restoring the composition of the Bacteroidetes flora，Conducive to the reconstruction of intestinal flora。In comparison，LevofloxacinTreatment significantly reduced Bacteroidetes and increased FirmicutesQuantity, disrupting the gut microbiotathereby increasingInfectionSex。These findings not only highlight the mechanism of action of Chinese herbal formulas，And expandedPulsatilla soupAs a veterinary drug、The application of feed additives and premixes in improving the production of animal-derived foods。

Picture1：Pulsatilla decoction and levofloxacin ingredients (A) and detection of intestinal flora structure after bet365 online sports betting mobiletreatment of E. coli infection (B）

Picture2 : Pulsatilla soup (PD) and levofloxacin (LVX) Changes in intestinal flora composition after bet365 online sports betting mobiletreatment of E. coli infection.

Also, the teamResearch Discovery，TCM prescriptions rely on the host’s own defense system to jointly regulate bacterial infection，Pulsatilla decoction can activate neutrophils to kill bacteria by regulating microvascular endothelial cells，Early team proof: in the bloodNeutrophils (Neutrophil PMN）Can only swallow bacteria but cannot kill them，But when crossing non-damaged microvascular endothelial cells（MVECs）The infecting bacteria can be cleared later, but after passing through the damageMVECsCan’t kill bacteria after all（Immunol. Res, 2016, 64,133~142.），This explainsMVECsis activatedPMNKey cells for sterilization. The team’s new research progress proves that endothelial-derived leukocytosisMesogen1α（IL-1α）Can promote the intracellular and extracellular bactericidal effect of transendothelial neutrophils，Mainly passed11Continuous action of seed protein，These proteins are mainly located on the membrane system of endothelial cells。Research results foundBacteriaLipopolysaccharide (LPS）Inhibited endothelial cellsIL-1α's release，And further inhibits the ability of bacteria to kill transendothelial neutrophils。

      Picture3: Establishment of an interaction platform between intestinal mucosal microvascular endothelial cells and neutrophils (A); Microvascular endothelial cells were successfully screenedIL-1αThe protein that promotes the bactericidal function of neutrophils is mainly located on the cell membrane (B); found to be common to all three time points5Proteins are upregulated simultaneously5Proteins bet365 online sports betting mobilewere down-regulated at the same time (C); there are a total of differential proteins that continue to change11kind(D); we found that one of these proteinsENPLis located on the mitochondrial membrane and is first up-regulated and then down-regulated (E）；In the signaling pathways regulated by these proteins，Early stage is the regulation of intercellular adhesion molecules，The later stage is the continuous activation of oxidative phosphorylation (F); Endothelial origin indicatedIL-1αin promoting transendothelial neutrophil bactericidal function (G）。