Recently，Professor Jiang Linshu’s team from the Beijing Key Laboratory of Dairy Nutrition of our school has published three series of research papers in the top international dairy science journal "Journal of Dairy Science" and the food science journal "Antioxidants"，Multi-omics reveals disrupted immunometabolic homeostasis and oxidative stress in adipose tissue of dairy cows with subclinical ketosis: A sphingolipid-centric perspective》《Dietary supplementation of。The paper points out that serum sphingolipids are biomarkers of differences in body fat mobilization during the perinatal period，The accumulation of sphingolipids in the adipose tissue of cows with subclinical ketosis caused by severe lipolysis may be the cause of metabolic disorders，Further proof that naringin can improve lactation performance and adipose tissue metabolic health of postpartum dairy cows by regulating sphingolipid metabolism。
The perinatal period is critical to milk production and reproductive performance throughout the lactation cycle。Due to asynchronous recovery of dry matter intake and peak lactation，Bet365 gamesCauses negative energy balance in transition period cows，Need to mobilize fat to alleviate insufficient energy intake。Severe negative energy balance leading to excessive lipolysis，Resulting in increased susceptibility to metabolic diseases in early lactation cows，Severe impact on the health and performance of dairy cows。The team discovered it first，Excessive body fat mobilization in dairy cows is accompanied by decreased systemic insulin sensitivity、Impaired liver function、Increased oxidative stress and inflammatory response，It was also found that serum differential metabolites and lipids at different sampling time points during the perinatal period were all enriched in sphingolipid metabolism。
Analysis of differential metabolite pathways in serum of high and low body fat mobilized cows
The team further discovered subclinical ketosis in dairy cows during the peripartum period，The serum non-esterified fatty acid and pro-inflammatory factor concentrations in subclinical ketosis cows are higher than those in healthy cows，Antioxidant capacity and adiponectin levels are lower than healthy cows。Transcriptomic discovery of ceramide biosynthesis in adipose tissue、Upregulation of genes related to lipolysis and inflammation，And catabolism with ceramide、Adipogenesis、Downregulation of genes related to adiponectin production and antioxidant enzyme system，Changes in related genes consistent with accumulation of ceramide and sphingomyelin in adipose tissue。Research has shown that sphingolipid metabolism, Bet365 gamesespecially ceramide accumulation, is responsible for the disorder of glycolipid metabolism in dairy cows during the peripartum period、Key factors inducing metabolic diseases。
Multi-omics analysis of serum and adipose tissue of subclinical ketosis cows and healthy cows
Combined with previous research results on citrus flavonoids，The team found that feeding naringin, the main component of citrus flavonoids, reduced serum non-esterified fatty acids in perinatal cows、C-reactive protein、IL-1β、IL-6、malondialdehyde、Lipopolysaccharide、Alanine aminotransferase and aspartate aminotransferase levels，Also increases adiponectin abundance in adipose tissue、Reduce inflammatory response and reduce oxidative stress。Lipidomics and proteomics analysis of adipose tissue further explained，Feeding naringin may reduce ceramide accumulation by reducing serum non- and lipopolysaccharide levels and increasing adiponectin expression，Thereby reducing inflammation and oxidative stress in adipose tissue，Relief of glucose and lipid metabolism disorders caused by excessive lipolysis，Ultimately improve its systemic metabolic status and improve lactation performance。
The mechanism of action of naringin in improving the metabolic status of dairy cows during the peripartum period
Zhao Huiying, a master's student in the School of Animal Science (published in Journal of Dairy Science and Antioxidants) and Li Youxue (published in Antioxidants) are the first authors of the series of papers，Professor Jiang Linshu、Associate Professor Zhao Yuchao is the corresponding author of the paper。The research work was supported by the National Natural Science Foundation of Bet365 gamesChina (32302767)、Beijing Natural Science Foundation (6232004)、Supported by Beijing Agricultural College Young Teachers’ Scientific Research and Innovation Ability Improvement Program (QJKC-2023016) and other projects。
The head of the Beijing Key Laboratory of Dairy Nutrition in the school said，The team will fully implement the spirit of the school’s Fourth Party Congress，Close to “pay close attention to work implementation，Promoting high-quality development” theme line，Continuously improve scientific research and innovation capabilities，Continuously produce high-level innovative results，Make new and greater contributions to the construction of a domestic first-class and internationally renowned urban agriculture and forestry characteristics high-level application-oriented university。
