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National Cancer Registration Center Statistics，my country added 429 in 2015.20,000 tumor cases and 281.40,000 deaths，Tumor diseases are increasingly serious and endanger people’s happiness and health。Prevention of tumor diseases is more important than treatment，However, tumor drugs often have toxic side effects，Not suitable for daily use by healthy people to prevent tumor occurrence。Discovering non-toxic and effective tumor prevention and treatment drugs from the secondary metabolites naturally formed by plants is an effective way to prevent and treat tumor diseases overall。A research team led by Professor Ma Lanqing and Associate Professor Dou Dequan of Beijing Agricultural University found that some triterpenoid compounds in Luo Han Guo not only have no toxic side effects but also have the effect of directly killing tumor cells。

Professor Ma Lanqing and Associate Professor Dou Dequan of Beijing bet365 online sports betting appAgricultural College and researcher Sun Yuanxia of Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences、Professor Rong Long and Professor Rong Yonghai of Beihang University have conducted collaborative research for many years，Isolation of natural secondary metabolites of plants、After screening, it was found that some triterpenoid compounds in Luo Han Guo not only have no toxic side effects but also have the effect of directly killing tumor cells，To develop tumor prevention、Therapeutic drugs provide new ideas。

Mangosteen is a plant endemic to Guangxi, my country，The Pharmacopoeia records that Luo Han Guo has the effect of clearing the throat and moistening the lungs。The triterpene saponins in Luo Han Guo fruit have high sweetness (300-400 times that of sucrose)、Features of low calorie and no toxic side effects，In Food、It has important application and commercial value in the fields of health products and medicine。The research team screened a variety of plant metabolites in the early stage，The triterpenoid saponins in Luo Han Guo have a significant killing effect on pancreatic cancer, the “king of cancers”，At the same time, it can extend the lifespan of animals with tumors，For lung cancer、Leukemia、Liver cancer、Laryngeal cancer、A variety of malignant tumors such as lymphoma and colon cancer have killing effects。

In addition，The research team also found that triterpenoids in Luo Han Guo can block the cell cycle、Inhibiting bet365 online sports betting mobiletumor cell metastasis and other functions。Pharmacological studies show that Luo Han Guo triterpenoid saponins regulate p21、CyclinD1 and other cyclins arrest tumor cells in the G0/G1 phase，And induce tumor cell apoptosis by regulating the Bcl-2 protein family。Research has discovered for the first time multiple signaling targets of Luo Han Guo triterpenoid saponins inducing tumor cell apoptosis，Provides a pharmacological basis for the development of tumor prevention and treatment drugs。

Relevant research has been published inbet365 online sports bettingJournalsOncogenesisPrevious。Dr. Liu Can, School of Biological Sciences and Engineering, Beijing Agricultural University, and Dr. Dai Longhai, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, are the co-first authors of the paper。Relevant intellectual property rights involved in this research have applied for a number of international invention patents and national invention patents。