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Recently，Professor Jiang Linshu’s team from the Beijing Key Laboratory of Dairy Nutrition of our school has published three series of research papers in the top international dairy science journal "Journal of Dairy Science" and the food science journal "Antioxidants"，Multi-omics reveals disrupted immunometabolic homeostasis and oxidative stress in adipose tissue of dairy Bet365 login with subclinical ketosis: A sphingolipid-centric perspective》《Dietary supplementation of naringin improves systemic metabolic status and alleviates oxidative stress in transition Bet365 login via modulating adipose tissue function: A lipid perspective》。The paper points out that serum sphingolipids are biomarkers of differences in body fat mobilization during the perinatal period，The accumulation of sphingolipids in the adipose tissue of Bet365 login with subclinical ketosis caused by severe lipolysis may be the cause of metabolic disorders，Further proof that naringin can improve lactation performance and adipose tissue metabolic health of postpartum dairy Bet365 login by regulating sphingolipid metabolism。

The perinatal period is critical to milk production and reproductive performance throughout the lactation cycle。Due to the asynchronous recovery of dry matter intake and peak lactation，Causes negative energy balance in transition bet365 online casinoperiod Bet365 login，Need to mobilize fat to alleviate insufficient energy intake。Severe negative energy balance leading to excessive lipolysis，Resulting in increased susceptibility to metabolic diseases in early lactation Bet365 login，Severe impact on the health and performance of dairy Bet365 login。The team discovered it first，Excessive body fat mobilization in dairy Bet365 login is accompanied by decreased systemic insulin sensitivity、Impaired liver function、Increased oxidative stress and inflammation，It was also found that serum differential metabolites and lipids at different sampling time points during the perinatal period were all enriched in sphingolipid metabolism。

Analysis of differential metabolite pathways in serum of high and low body fat mobilized dairy Bet365 login

The team further discovered subclinical ketosis in dairy Bet365 login during the peripartum period，The serum concentrations of non-esterified fatty acids and pro-inflammatory factors in subclinical ketosis Bet365 login are higher than those in healthy Bet365 login，Antioxidant capacity and adiponectin levels are lower than healthy Bet365 login。Transcriptomic discovery of ceramide biosynthesis in adipose tissue、Upregulation of genes related to lipolysis and inflammation，With ceramide catabolism、Adipogenesis、Down-regulation of genes related to adiponectin production and antioxidant enzyme system，Changes in related genes consistent with accumulation of ceramide and sphingomyelin in adipose tissue。Research has shown that sphingolipid metabolism, especially ceramide accumulation, is responsible for glucose and lipid metabolism disorders in dairy Bet365 login during the peripartum period、Key factors inducing metabolic diseases。

Multi-omics analysis of serum and adipose tissue bet365 online sports betting appof subclinical ketosis Bet365 login and healthy Bet365 login

Combined with previous research results on citrus flavonoids，The team’s research found that feeding naringin, the main component of citrus flavonoids, reduced serum non-esterified fatty acids in perinatal Bet365 login、C-reactive protein、IL-1β、IL-6、malondialdehyde、Lipopolysaccharide、Alanine aminotransferase and aspartate aminotransferase levels，Also increases adiponectin abundance in adipose tissue、Reduce inflammatory response and reduce oxidative stress。Lipidomics and proteomics analysis of adipose tissue further explained，Feeding naringin may reduce ceramide accumulation by reducing serum non- and lipopolysaccharide levels and increasing adiponectin expression，Thereby reducing inflammation and oxidative stress in adipose tissue，Relief of glucose and lipid metabolism disorders caused by excessive lipolysis，Ultimately improve its systemic metabolic status and improve lactation performance。

The mechanism of action of naringin in improving the metabolic status of dairy Bet365 login during the peripartum period

Zhao Huiying, a master's student in the School of Animal Science (published in Journal of Bet365 login Science and Antioxidants) and Li Youxue (published in Antioxidants) are the first authors of the series of papers，Professor Jiang Linshu、Associate Professor Zhao Yuchao is the corresponding author of the paper。The research work was supported by the National Natural Science Foundation of China (32302767)、Beijing Natural Science Foundation (6232004)、Supported by Beijing Agricultural College Young Teachers’ Scientific Research and Innovation Ability Improvement Plan (QJKC-2023016) and other projects。

The head of the Beijing Key Laboratory of Bet365 login Nutrition in the school said，The team will fully implement the spirit of bet365 online sports betting mobilethe school’s Fourth Party Congress，Close to “pay close attention to work implementation，Promoting high-quality development” theme line，Continuously improve scientific research and innovation capabilities，Continuously produce high-level innovative results，Make new and greater contributions to the construction of a domestic first-class and internationally renowned urban agricultural and forestry characteristics high-level application-oriented university。